Tumor Suppressor Human Beta Defensin-1 (hBD-1) Modulates HER2 Signaling

In a new study by Sun et al., it was found that the tumor-suppressing effect of hBD-1 is associated with its ability to interact directly with the HER2 receptor, and modulate EGFR/HER2-associated signaling pathway in breast cancer. Phigenix’s technology invented by its founder Dr. Carlton Donald, focuses on targeting the PAX2 oncogene, which he discovered suppresses hBD-1 expression. He also was the first to demonstrate that inhibiting PAX2 results in the re-expression of hBD-1 and cancer cell death. This study further supports the development of a PAX2 inhibitor as a novel therapy for breast cancer.